Ciprofloxacin-resistant Haemophilus influenzae strains possess mutations in analogous positions of GyrA and ParC
نویسندگان
چکیده
منابع مشابه
Novel gyrA and parC point mutations in two strains of Acinetobacter baumannii resistant to ciprofloxacin.
non-nucleoside reverse transcriptase inhibitor resistance due to the low genetic barrier to resistance and relatively preserved fitness of non-nucleoside reverse transcriptase inhibitor-resistant virus. 9 While the relationship between adherence and resistance may be complex, we want to be completely clear that we are not suggesting that good adherence is bad. Even with early HAART, every 10% i...
متن کاملAssociation between mutations in gyrA and parC genes of Acinetobacter baumannii clinical isolates and ciprofloxacin resistance
Objective(s): We investigated the contribution of gyrA and parC mutational mechanism in decreased ciprofloxacin susceptibility of Acinetobacter baumannii isolated from burn wound infections. Materials and Methods: Ciprofloxacin susceptibility of 50 A. baumannii isolates was evaluated by disk diffusion and agar dilution methods. PCR and sequencing were performed for detection of mutation in gyr...
متن کاملassociation between mutations in gyra and parc genes of acinetobacter baumannii clinical isolates and ciprofloxacin resistance
objective(s): we investigated the contribution of gyra and parc mutational mechanism in decreased ciprofloxacin susceptibility of acinetobacter baumannii isolated from burn wound infections. materials and methods: ciprofloxacin susceptibility of 50 a. baumannii isolates was evaluated by disk diffusion and agar dilution methods. pcr and sequencing were performed for detection of mutation in gyra...
متن کاملAssociation between mutations in gyrA and parC genes of Acinetobacter baumannii clinical isolates and ciprofloxacin resistance
OBJECTIVES We investigated the contribution of gyrA and parC mutational mechanism in decreased ciprofloxacin susceptibility of Acinetobacter baumannii isolated from burn wound infections. MATERIALS AND METHODS Ciprofloxacin susceptibility of 50 A. baumannii isolates was evaluated by disk diffusion and agar dilution methods. PCR and sequencing were performed for detection of mutation in gyrA a...
متن کاملgyrA mutations in ciprofloxacin-resistant Bartonella bacilliformis strains obtained in vitro.
We isolated and characterized mutants of Bartonella bacilliformis that are resistant to the fluoroquinolone antibiotic ciprofloxacin, which targets the A subunit of DNA gyrase. Mutants had single point mutations in the gyrA gene that changed either Asp-90 to Gly or Asp-95 to Asn and had 3- or 16-fold higher resistance, respectively, to ciprofloxacin than did wild-type B. bacilliformis. Asp-95 i...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1996
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.40.7.1741